|A photo from yesterday's celebration--Bertrand's favorite birthday party!|
When you were born, I joked that I loved you so much that I didn't care in which field you got your Ph.D.
I had no idea that by 5 years old, someone would end up getting their Ph.D. in you.
You've led many on a journey through extremes in the human experience.
Today, I'm grateful that you're still here to lead.
May it always be so.
Happy birthday! :)
--Matt (aka Daddy)
Reed: Tell us about this new breakthrough in stem cell technology that allows you to create “disease in a dish” models using cells derived from stem cells. What is it all about?”Jackson: It’s a very exciting new advancement. It allows us to take patients’ own cells and, if a patient has a disease that affects those cells, to measure that defect. This is done through advances in quantitative microscopy, mixed with or alongside of robotic drug screening; the two together are quite a spectacular shortcut to be able to see whether a medicine we already have today that is being prescribed for one disease might have utility in another.Now, you say, how could that be? There are a number of very spectacular examples out there of drugs that have been used or developed for one indication and then later on have been found to have a different clinical utility. In the specific example we’re talking about here with disease in a dish, we’re initially focusing on rare diseases. With rare diseases, the children’s cells all have a particular defect, and it’s that defect that we can actually recapitulate and rebuild in a dish, the so-called disease in a dish. Then, using robotics and screening technology and using the kind of equipment you’re seeing behind you here, to search in a systematic way and see whether any preexisting drugs that are already approved could move the needle and improve the defect in the child’s cells.